Raloxifene 4-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4-glucuronide binds to estrogen receptor with an IC50 of 370 µM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFbeta3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].
Molecular Weight:
649.71
Purity:
98.19
CAS Number:
[182507-22-8]
Formula:
C34H35NO10S
Target:
Estrogen Receptor/ERR
Application Notes:
MCE Product type: Reference compound1
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