Bavarostat (EKZ-001) is a blood-brain barrier-permeable, potent HDAC6 inhibitor and PET radiotracer, with an IC50 as low as 17 nM against human HDAC6. Bavarostat can be labeled with 18F and used as a probe to map HDAC6 distribution and measure target occupancy in the brains of non-human primates. Bavarostat also selectively modulates tubulin acetylation, but not histone acetylation. Bavarostat is applicable for research on Alzheimers disease, other neurodegenerative disorders, and cancers[1][2][3].
Molecular Weight:
346.44
Purity:
99.51
CAS Number:
[2134109-20-7]
Formula:
C20H27FN2O2
Target:
HDAC,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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