AT 1001 is a high-affinity and selective antagonist of the alpha3beta4 nicotinic acetylcholine receptor (alpha3beta4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with alpha3beta4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies[1].
Molecular Weight:
309.24
Purity:
99.94
CAS Number:
[1314801-63-2]
Formula:
C15H21BrN2
Target:
nAChR
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
