SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].
Molecular Weight:
285.73
Purity:
98.81
CAS Number:
[1807758-81-1]
Formula:
C15H12ClN3O
Target:
Apoptosis,Sirtuin
Application Notes:
MCE Product type: Reference compound
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