BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1].
Molecular Weight:
353.38
Purity:
99.76
CAS Number:
[2408648-20-2]
Formula:
C18H19N5O3
Target:
Apoptosis,FGFR
Application Notes:
MCE Product type: Reference compound
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