iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A)[1].
Molecular Weight:
323.35
Purity:
99.96
CAS Number:
[150651-39-1]
Formula:
C20H13N5
Target:
Ferroptosis,Ligands for Target Protein for PROTAC
Application Notes:
MCE Product type: Reference compound
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