bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-beta and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNgamma). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].
Molecular Weight:
350.24
Purity:
98
CAS Number:
[42494-73-5]
Formula:
C12H8KN2O5V
Target:
Apoptosis,Parasite,Phosphatase,PTEN
Application Notes:
MCE Product type: Reference compound
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