BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
Molecular Weight:
819.91
Purity:
99.07
CAS Number:
[2349356-39-2]
Formula:
C42H49N11O7
Target:
CDK,PROTACs
Application Notes:
Reference compound
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