THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kalpha. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kalpha/beta/gamma. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
Molecular Weight:
531.61
Purity:
99.54
CAS Number:
[2058075-45-7]
Formula:
C31H29N7O2
Target:
Autophagy
Application Notes:
MCE Product type: Reference compound
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