MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis[1].
Molecular Weight:
636.73
Purity:
99.68
CAS Number:
[2134169-43-8]
Formula:
C32H35F3N8OS
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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