ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated beta-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons[1].
Molecular Weight:
379.45
Purity:
99.39
CAS Number:
[1386162-69-1]
Formula:
C22H25N3O3
Target:
Dopamine Receptor
Application Notes:
MCE Product type: Reference compound
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