Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs)[1].
Molecular Weight:
468.52
CAS Number:
[1239269-51-2]
Formula:
C25H29FN4O4
Target:
c-Kit,PDGFR,VEGFR
Application Notes:
MCE Product type: Reference compound
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