CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells[1][2][3][4].
Molecular Weight:
507.53
Purity:
98.38
CAS Number:
[1352914-52-3]
Formula:
C28H29NO8
Target:
Apoptosis,Eukaryotic Initiation Factor (eIF)
Application Notes:
MCE Product type: Reference compound
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