S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells[1].
Molecular Weight:
451.94
Purity:
98.44
CAS Number:
[2262488-39-9]
Formula:
C23H28ClF2N3O2
Target:
Apoptosis,Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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