RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells[1].
Molecular Weight:
365.34
Purity:
98.57
CAS Number:
[919091-63-7]
Formula:
C19H15N3O5
Target:
Apoptosis,Deubiquitinase
Application Notes:
MCE Product type: Reference compound
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