IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the cancer stem cells in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research[1].
Molecular Weight:
423.63
CAS Number:
[878204-96-7]
Formula:
C28H41NO2
Target:
Hedgehog,Smo
Application Notes:
MCE Product type: Reference compound
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