Aftin-5 is an inducer for Amyloid-beta 42 (Abeta42). Aftin-5 upregulates Abeta42 and downregulates Abeta38 levels in a beta-secretase- and gamma-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AbetaPP695, with IC50s of 180, 194, 178 and 150 µM, respectively[1].
Molecular Weight:
354.45
Purity:
99.70
CAS Number:
[1461717-05-4]
Formula:
C19H26N6O
Target:
Amyloid-beta
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted