TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3beta) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3beta, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3beta. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3beta[1].
Molecular Weight:
529.58
CAS Number:
[436866-52-3]
Formula:
C30H31N3O6
Target:
GSK-3
Application Notes:
MCE Product type: Reference compound
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