MitoPBN is a AMPK/SIRT3/PGC-1alpha axis modulator, reactive oxygen species scavenger and mitochondrial function enhancer. MitoPBN increases the phosphorylation level of AMPK, restores SIRT3 expression and reverses the down-regulation of PGC-1alpha, thereby promoting mitochondrial biogenesis. MitoPBN regulates glucose metabolism, reduces blood glucose by inhibiting hepatic gluconeogenesis and increasing hepatic glucose uptake, while scavenging mitochondrial superoxide anion/hydrogen peroxide, maintaining membrane potential and increasing ATP production. MitoPBN also reduces cell apoptosis (apoptosis), improves sperm motility, survival rate and membrane integrity, but may induce reductive stress in cryopreserved sperm at high concentrations. MitoPBN is widely applicable to research related to diabetes and type 2 diabetes[1][2][3].
Molecular Weight:
590.53
Purity:
95.00
CAS Number:
[652968-37-1]
Formula:
C33H37BrNO2P
Target:
AMPK,Apoptosis,PGC-1alpha,Reactive Oxygen Species (ROS),Sirtuin
Application Notes:
MCE Product type: Reference compound1
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