SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of alpha-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases[1][2][3][4].
Molecular Weight:
491.58
CAS Number:
[854402-59-8]
Formula:
C25H37N3O7
Target:
Calcium Channel,Proteasome,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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