USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2].
Molecular Weight:
510.05
Purity:
99.09
CAS Number:
[2413944-70-2]
Formula:
C27H28ClN3O3S
Target:
Deubiquitinase,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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