Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-beta-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inammation in vascular smooth muscle cells (VSMCs)[1].
Molecular Weight:
260.68
Purity:
98.72
CAS Number:
[848142-62-1]
Formula:
C13H9ClN2O2
Target:
COX,Estrogen Receptor/ERR
Application Notes:
Reference compound
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