(+)-ITD-1 is an inhibitor for TGF-beta, that inhibits the TGF-beta2 with an IC50 of 0.46 µM. (+)-ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs)[1].
Molecular Weight:
415.52
CAS Number:
[1409968-46-2]
Formula:
C27H29NO3
Target:
TGF-beta/Smad,TGF-beta Receptor
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted