Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].
Molecular Weight:
240.25
Purity:
99.89
CAS Number:
[81267-65-4]
Formula:
C15H12O3
Target:
Apoptosis,Caspase,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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