SB1-G-187 is a GNF-7-based multi-kinase PROTAC degrader that induces potent degradation of YES1, IRAK1, LYN, etc. SB1-G-187 mediates kinase degradation in a partially p97/VCP-dependent manner. SB1-G-187 can be utilized to develop new strategies for treating difficult diseases (Pink: multi-kinase ligand (HY-125142), Blue: CRBN ligand (HY-A0003))[1].
Molecular Weight:
1022.03
Purity:
98.70
CAS Number:
[2769753-18-4]
Formula:
C52H54F3N9O10
Target:
Bcr-Abl,IRAK,PROTACs,Src
Application Notes:
MCE Product type: Reference compound
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