Edralbrutinib, CAS [[1858206-58-2]]

Product Overview

• Article Name: Edralbrutinib, CAS [[1858206-58-2]]
• Biozol Catalog Number: MCE-HY-137438
• Supplier Catalog Number: HY-137438
• Alternative Catalog Number: MCE-HY-137438-5MG,MCE-HY-137438-1MG,MCE-HY-137438-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: TG-1701

Product Description

Edralbrutinib (TG-1701) is a highly selective, orally available irreversible BTK inhibitor, with an EC50 of 6.70 nM and a Ka of 3 nM against human BTK. Edralbrutinib inhibits downstream signaling of the B cell receptor, induces dephosphorylation of Ikaros Ser442/445, promotes nuclear exclusion of Ikaros, regulates the expression of Ikaros target genes, attenuates Ikaros gene signatures, and exerts anti-tumor activity. Edralbrutinib can be used in research related to B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma[1][2].

Product Properties

• Molecular Weight: 489.47
• Purity: 99.75
• CAS Number: [1858206-58-2]
• Formula: C26H21F2N5O3
• Target: Btk

Application Notes

• Application Notes: MCE Product type: Reference compound