Icapamespib (PU-HZ151, PU-AD) is a selective, orally active inhibitor of Epichaperomes assembled by HSP90 with slow dissociation kinetics. Icapamespib can cross the blood-brain barrier (BBB) ??and induce epichaperome disassembly by non-covalently binding to HSP90, restoring the normal protein-protein interaction network. Icapamespib can specifically disrupt disease-related abnormal protein interaction networks, reduce neurotoxic protein aggregation and tumor cell survival signals. Icapamespib can be used in the research of neurodegenerative diseases such as Alzheimers disease, as well as cancers such as glioblastoma and metastatic breast cancer[1][2][3].
Molecular Weight:
526.39
Purity:
99.60
CAS Number:
[1000999-96-1]
Formula:
C19H23IN6O2S
Target:
HSP
Application Notes:
MCE Product type: Reference compound
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