Sitagliptin-d6, CAS [[1133211-99-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-13749S3
Supplier Catalog Number:
HY-13749S3
Alternative Catalog Number:
MCE-HY-13749S3-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
MK-0431-d6
Sitagliptin-d6 (MK-0431-d6) is deuterium labeled Sitagliptin (HY-13749). Sitagliptin is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes.
