Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. (Note: The solution should be prepared protected from light, freshly made before use, and storage is not recommended.). Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757)[6].
Molecular Weight:
371.51
Purity:
99.96
CAS Number:
[10540-29-1]
Formula:
C26H29NO
Target:
Apoptosis,Autophagy,Estrogen Receptor/ERR,HSP
Application Notes:
MCE Product type: Reference compound
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