TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKbeta phosphorylation, NF-kappaB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimers disease[1][2][3][4].
Molecular Weight:
260.40
CAS Number:
[769856-81-7]
Formula:
C8H12N4S3
Target:
Amyloid-beta,Beta-secretase,Drug Derivative
Application Notes:
MCE Product type: Reference compound1
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