TGF-betaRI inhibitor 3 (Compound 9ac) is a selective TGF-beta inhibitor. TGF-betaRI inhibitor 3 can effectively inhibit the TGF-beta signaling pathway. TGF-betaRI inhibitor 3 has IC50 values of 13 µM and 0.63 µM for c-Src kinase and ALK5 kinase, respectively[1].