NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-kappaB signaling. Antitumor activity[1][2].
Molecular Weight:
267.26
Purity:
99.93
CAS Number:
[343351-67-7]
Formula:
C11H9NO5S
Target:
Apoptosis,E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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