JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an alpha-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors[1][2][3].
Molecular Weight:
451.30
Purity:
99.54
CAS Number:
[2421119-60-8]
Formula:
C20H20Cl2N4O4
Target:
Ferroptosis,Glutathione Peroxidase
Application Notes:
MCE Product type: Reference compound
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