Collismycin A, CAS [[158792-24-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-138185
Supplier Catalog Number:
HY-138185
Alternative Catalog Number:
MCE-HY-138185-1MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
SF 2738A
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 µg/mL) and fungi (MICs=12.5-100 µg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s=0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50=56.6 µM) but not MDA-MD-231 breast cancer cells (IC50=>100 µM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 µM) prevents apoptosis in the brain region of zebrafish larvae in a model of neuronal cell death induced by all-trans retinoic acid.
Molecular Weight:
275.33
CAS Number:
[158792-24-6]
Formula:
C13H13N3O2S
Target:
Apoptosis,Bacterial
Application Notes:
MCE Product type: Natural Products
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