Lys-psi(CH2NH)-Trp(Nps)-OMe, CAS [[141365-20-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-138232
Supplier Catalog Number:
HY-138232
Alternative Catalog Number:
MCE-HY-138232-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
LTNAM
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.
Molecular Weight:
485.60
CAS Number:
[141365-20-0]
Formula:
C24H31N5O4S
Target:
Aminopeptidase
Application Notes:
MCE Product type: Reference compound
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