K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].
Molecular Weight:
287.74
Purity:
99.89
CAS Number:
[2563855-03-6]
Formula:
C16H14ClNO2
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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