Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM[1].
Molecular Weight:
723.90
Purity:
99.37
CAS Number:
[2229711-68-4]
Formula:
C45H49N5O4
Target:
Estrogen Receptor/ERR,PROTACs
Application Notes:
MCE Product type: Reference compound
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