AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 µM and 0.035 µM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 µM and 0.245 µM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].
Molecular Weight:
312.36
Purity:
99.30
CAS Number:
[847249-57-4]
Formula:
C18H20N2O3
Target:
Apoptosis,HDAC
Application Notes:
MCE Product type: Reference compound
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