BM-1244 (APG-1252-M1) is a Bcl-xL/Bcl-2 inhibitor with Kis of 134 nM and 450 nM. BM-1244 has anti-tumor effects by inducing apoptosis and suppressing tumor growth. BM-1244 can induce cytochrome C and Smac release from mitochondria with caspase-3 and PARP cleavage. BM-1244 exhibits synergy with chemotherapy in vivo. BM-1244 can be studied in research for colorectal cancer, acute myeloid leukemia and gastric cancer[1][2][3].
Molecular Weight:
1159.79
Purity:
99.85
CAS Number:
[1619923-32-8]
Formula:
C54H59ClF4N6O8S4
Target:
Apoptosis,Bcl-2 Family,Caspase,PARP
Application Notes:
MCE Product type: Reference compound
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