Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRbeta and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[1][2].
Molecular Weight:
658.69
Purity:
99.80
CAS Number:
[895519-91-2]
Formula:
C30H33F3N8O4S
Target:
Bcr-Abl,c-Kit,PDGFR
Application Notes:
MCE Product type: Reference compound
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