C6 Urea Ceramide (Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells. C6 Urea Ceramide (5-10 µM) inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated beta-catenin levels in HT-29 and HCT116 cells, and induces colocalization of beta-catenin with the 20S proteasome. C6 Urea Ceramide (1.25, 2.5, and 5 mg/kg) reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.
Molecular Weight:
426.68
CAS Number:
[486991-52-0]
Formula:
C25H50N2O3
Target:
Apoptosis,Autophagy,Ceramidase,beta-catenin
Application Notes:
MCE Product type: Reference compound
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