Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3 splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis[1].
Molecular Weight:
519.63
CAS Number:
[1609105-89-6]
Formula:
C28H41NO8
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Natural Products
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