IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1delta inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1delta[1][2].
Molecular Weight:
466.60
Purity:
99.93
CAS Number:
[686770-61-6]
Formula:
C22H18N4O2S3
Target:
Casein Kinase,Porcupine,Wnt
Application Notes:
MCE Product type: Reference compound
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