Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 µM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 µM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively, the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1].
Molecular Weight:
223.70
CAS Number:
[150403-96-6]
Formula:
C8H18ClN3O2
Target:
NO Synthase
Application Notes:
MCE Product type: Reference compound
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