Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and Arc expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Abeta42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimers disease[1][2][3].
Molecular Weight:
295.81
Purity:
99.85
CAS Number:
[2480226-07-9]
Formula:
C15H22ClN3O
Target:
Amyloid-beta,iGluR,mTOR,Tau Protein
Application Notes:
MCE Product type: Reference compound
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