Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). Zotizalkib has strong antitumor activities[1].
Molecular Weight:
447.41
Purity:
98.02
CAS Number:
[2648641-36-3]
Formula:
C21H20F3N5O3
Target:
Anaplastic lymphoma kinase (ALK)
Application Notes:
MCE Product type: Reference compound
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