CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 µM) and CDK9/Cyclin T1 (IC50=127 µM) at high ATP (2 mM) (WO2021116178A1)[1].
Molecular Weight:
454.36
Purity:
98.03
CAS Number:
[2651200-35-8]
Formula:
C18H15F5N8O
Target:
CDK
Application Notes:
MCE Product type: Reference compound
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