MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion[1].
Molecular Weight:
368.50
Purity:
99.56
CAS Number:
[896657-58-2]
Formula:
C20H24N4OS
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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