PX20350 is a FXR agonist with EC50s of 83 and 10 nM for mFXR and hFXR, respectively. PX20350 significantly induces NDRG2 mRNA expression. PX20350 potently reduces liver tumor cells (SK-GI-18 cells) growth and metastasis, and has anti-tumorigenic activity in orthotopic xenograft mouse models[1].
Molecular Weight:
592.39
CAS Number:
[1198085-23-2]
Formula:
C28H22Cl2F3N3O4
Target:
FXR
Application Notes:
Reference compound
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