ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 µM and 1.7 µM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 µM and 9.4 µM, respectively[1][2].
Molecular Weight:
429.58
Purity:
99.93
CAS Number:
[891016-02-7]
Formula:
C23H31N3O3S
Target:
Parasite,TRP Channel
Application Notes:
MCE Product type: Reference compound1
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